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A lack of vitamin B12 can lead to high levels of homocysteine in the blood which can damage the lining of the arteries and may also make the blood clot more easily, which can increase the risk of blood vessel blockages and contribute to cholesterol plaque build-up, increasing the risk of heart disease and stroke (Chiu et al., 2020)

Therefore, more recent research has shifted the focus to screening a drug that targets the lipotoxicity of individuals with fewer side effects to prevent and treat KOA [10, 11]

It is a further problem underlying the invention to provide a mild process, which avoids harsh conditions and harsh chemicals

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