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Following a week of acclimatization to the animal facilities, rats were handled for 2 min/ day for three days prior to the start of the experiments, in order to habituate to the experimenters

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We also gratefully acknowledge the support and use of facilities at the Morphology and Imaging Shared Facility and Regenerative Medicine Shared Facility provided at the Shriners Childrens Boston

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NAC is a pro-drug with an acetyl group linked to the nitrogen atom of cysteine, thus allowing better stability and absorption of cysteine