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[143] Edwin Cohn prepared a liver extract that was 50 to 100 times more potent in treating pernicious anemia than the natural liver products

doi: 10.1016/j.it.2022.02.003 24

Tryptophan increased also the circulating levels of melatonin, particularly in the portal circulation and these changes of melatonin levels in GIT following tryptophan application were unaffected by prior pinealectomy, but greatly reduced by a partial ligature of the portal vein (8)

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