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Hypoglycemia the primary preclinical safety signal for IGFBP-poor IGF variants

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Injectable B12 bypasses absorption issues and is first-line treatment for malabsorption conditions, whilst oral doses of 1,0002,000 g daily may suit dietary deficiency without malabsorption

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While these are prescribed for some patients with pernicious anaemia, it should be noted that these are only licensed for vitamin B12 deficiency of dietary origin and not pernicious anaemia[21]