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Increases in resting heart rate are a recognised class effect of incretin-based therapies and have been reported with GLP-1 receptor agonists more broadly, as reflected in the Summary of Product Characteristics (SmPC) for licensed agents such as semaglutide (Wegovy) and liraglutide (Saxenda)

Hormones are big

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In addition, it has been reported that Ferritin degradation caused by increased autophagy can promote ferroptosis in fibroblasts and cancer cells (Hou et al., 2016)

Statements Author contributions TH: Supervision, Visualization, Writing original draft, Formal analysis, Software, Data curation, Funding acquisition, Methodology, Validation, Conceptualization, Resources, Investigation, Project administration, Writing review & editing

The limited efficacy and potential adverse reactions of current treatments have led to a look for alternative strategies