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It aggravates RA by inducing gut dysbiosis, disrupting the intestinal barrier, and promoting a Th17-skewed immune response, often accompanied by increased generation of citrullinated proteins ( P.g weakens the gut barrier and permits its arthritogenic actions ( P.g also exacerbates inflammatory bowel disease (IBD) by directly degrading the tight junction protein ZO-1 via its gingipains, and by altering gut microbiota to expand IL-9-producing CD4+ T cells, which drive intestinal inflammation (Tsuzuno et al., 2021

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The integration of these applications into a cascading circular system is conceptualized in Figure 5, which illustrates the fungal biorefinery model

Roasted garlic contains less allicin per gram relative to raw garlic because the roasting process inhibits the activity of alliinase