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2) Reproducibility: the modeling process should be able to be constructed varying from different individuals, different experimental sites, etc., and the experimenter should be able to obtain a uniform molding effect according to the standard experimental protocol

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Specifically, Aos possess the ability to bind to metal ions, thereby promoting the redox activity of these metals [81,82,83]

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It is plausible that factors that play a role in redox homeostasis may play an impactful role in determining APR-246 sensitivity [48]

The thiol groups (R- SH) undergo deprotonation (loss of H + ), giving the thiolate form R-S -