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Astrocytes indirectly promote OL survival by inducing apoptosis in CD4+ T cells 182 , and peripheral immune cells in MS produce leukaemia inhibitor factor (LIF) which protects OLs from TNF-induced death in vitro 183

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These results suggested that chronic hypoxia promotes hyperphosphorylation of -syn through inhibition of PP2A activity and further inhibition of PP2A activity through p--syn, creating a vicious cycle