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In addition to SAM depletion, even inactive NNMT can interact with betaine-homocysteine methyltransferase (BHMT), methionine adenosyltransferase (MAT), and adenosylhomocysteinase (AHCY) to regulate methyl donor balance (96, 97)

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Step 4: Muscles and ligaments in the face start to loosen and bones have now started to resorb

Our interpretation of this result may be that the decrease in TSH levels can be attributed to the role of vitamin B12, which supports the manufacture of thyroid hormones, and the increase in T3 and T4 levels through a feedback mechanism