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Differential thiol oxidation of the signaling proteins Akt, PTEN or PP2A determines whether Akt phosphorylation is enhanced or inhibited by oxidative stress in C2C12 myotubes derived from skeletal muscle

Among these pathways, hepatic triglyceride accumulation is particularly associated with impaired fatty acid oxidation and saturated VLDL secretion capacity, contributing to the persistence and progression of steatosis [77,78,79] (Fig

Mechanistically, PPAR interacts with the C-terminal domain of p53, inhibiting its acetylation and disrupting the interaction between p53 and GSK3

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