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Both nitric oxide and glutathione exert protective functions on the intestinal epithelium

We used a similar strategy to prepare the two peptides for NCL, as previously optimized for the synthesis of the d-Abl SH2 domain including the usage of the 3-amino-4-(methylamino)benzoic acid (MeDbz) linker and N-terminal capping strategy 34

The enzyme injections can cause a brief stinging sensation, but a medical-grade topical numbing cream is applied beforehand to minimize any discomfort

Details on flux calculations are provided in Supplementary Information

This therapy is often referred to as an EBOO blood treatment or EBOO ozone therapy, exposing 2-3 liters of blood to continuous 7-14 gamma oxygen-ozone gas

De Pauw, A., Tejerina, S., Raes, M., Keijer, J