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It has been shown that pathogenic bacteria or viruses in inflamed tissues promote ferroptosis in cells while activating immune cells and triggering inflammatory responses through the action of lipopolysaccharides, peptidoglycans, bacterial or viral DNA, and host cell toll-like receptors carried or released by themselves (60)

Table 1 Diverse sources and types of polyphenols, their antioxidant properties, and modes of action

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The free radicals generated from these reactions can affect DNA, with substitutions of some DNA bases such as guanine with cytosine, guanine with thymine and cytosine with thymine (Jan et al., 2015)

Any unusual or persistent reaction should be evaluated by a healthcare professional immediately