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To further test the crucial role of GSH in the acute phase of colitis, we analyzed the effect of NAC, a GSH precursor, on mucosal GSH levels in relation with the TNBS-induced colitis

Alongside NLRP3 activation, circulating cell-free mitochondrial DNA (ccf-mtDNA) release was also significantly reduced by similar levels following MCC950 and BFE treatment, indicating that both interventions mitigated mitochondrial stress in BD and CT COs (Fig

Sterigmatocystin: Occurrence, toxicity and molecular mechanisms of action A review

Clearance of lipid peroxides Several free radical trapping antioxidants (RTAs), such as -tocopherol (the active form of vitamin E), ferrostatin-1 (Fer-1), and liproxstatin-1 (Lip-1), have demonstrated efficacy in scavenging lipid peroxides for the treatment of PF [24, 156]