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However, given their high evidentiary power, RCTs remain valuable for establishing causal relationships following observational studies

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It is worth mentioning that a recent study found that in tumors, the metabolite lactate affected the TME by regulating the lactylation of MOESIN in Tregs and enhancing TGF- signal transduction, thus promoting a new mechanism of tumorigenesis 266

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There is limited clinical data published on intrathecal iron chelation in neurodegeneration, and no iron chelator is officially approved for IT use, given that this is a rather invasive experimental approach

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Another feature of cytosolic and nuclear ISC biogenesis that is similar to mitochondrial ISCs biogenesis is the dependency on a supply of electrons (Webert et al., 2014)

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Jin Y, Lu L, Tu W, Luo T, Fu Z

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Iddrisu Sulemana

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