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Rats were housed in a humidity- (50 5%) and temperature-controlled (23 2) room, under a 12/12 h light (200 lux)/dark cycle, with rodent standard chow and water available ad libitum

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Identification of isonicotinoylhydrazones of pyruvic and alpha-ketoglutaric acid in rat urine after treatment with isonicotinic acid hydrazide (isoniazid)

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(87) noted in their review that co-encapsulation systems can effectively mask the astringency of different bioactive compounds, enhance their stability and bioavailability, and maximize their biological effects through synergistic interactions