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Notably, the mutation frequencies of four genes, including VHL, PBRM1, SETD2, and BAP, exceeded 10%

This work integrates synthetic design, kinetic study, supramolecular characterization, computational modeling, and biological application to provide a blueprint for developing advanced molecular machines with biomedical functionality

We diagnose it using the Rome IV clinical criteria, which require recurrent abdominal pain linked to changes in stool frequency or form

The mutants exhibited a significant effect on the nanobodies stability, as evidenced by the Cartesian ddG values ranging from -8.9 kcal/mol to 63.8 kcal/mol for PV2 and 9.4 kcal/mol to 73.3 kcal/mol for PV3

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GHK-Cu also shows cytoprotective effects in the gastrointestinal tract