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Clinical trials use either folic acid (a synthetic formula that is converted into folate) or the active form of folate, methylfolate

doi: 10.1038/nrn2417 129

The primary risk is bacterial infection a vial left at room temperature for 12+ hours can harbor pathogens that cause injection-site abscesses, cellulitis, or systemic infection if they enter the bloodstream

Furthermore, elevated levels of markers for glial cells (GFAP and Sox-10) and multiple pro-inflammatory cytokines are found in colon biopsy samples from individuals suffering from PD (65)