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For instance, mephedrone increases both dopamine and serotonin release, whereas -PVP primarily targets dopamine and norepinephrine transporters (Simmler et al., 2013)

Cell Mol Neurobiol

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Epilepsia 1996, 37: 687-689

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In addition to blocking coactivator binding, H12 repositioning allows the recruitment of corepressors such as nuclear receptor co-repressor 1 (NCoR) and silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) (PDB: 1KKQ) (Figure 4D) 93