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ERG reacts fast with hydroxyl radicals, and its reaction with hydrogen peroxide and superoxide radical anion is somewhat slower (Fahey 2001)

During nitrogen starvation, Rpc53 is hyperphosphorylated and inactivated, leading to a decrease in ribosome biogenesis ( Fig

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As it involves a reduced supply of oxygen to the brain, tissue hypoxia triggers vital molecular pathways such as excitotoxicity, oxidative stress, apoptosis, and inflammation that inevitably lead to cell death