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Brck J, Dringen R, Amasuno A, Pau-Charles I, Ghoreschi K

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However, the accumulation of GlcCer in the lysosomes due to the impairment of the GCase enzyme leads to global lysosomal impairment, inflammation, and cell death, ultimately resulting in microglial activation, astrocytosis, and neuronal death in layers III and V of the cortex and hippocampal regions as observed in GD2 models [8]

Potential conservation of condensin-mediator interaction in human cells Since condensin and mediator are conserved in both fission yeast and humans, the condensin-mediator interaction might also be conserved in human cells

The thermal program was as follows: initial denaturation at 98C for 3 min and 40 cycles (95C/10 s, 60C/30 s)