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Furthermore, the gastrointestinal tract also has a major role in metformin action through modulation of glucose-lowering hormone glucagon-like peptide 1 and the intestinal bile acid pool and alterations in gut microbiota composition

Strasburger, C

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

doi: 10.1038/nature15252 223 CullAHSnetsingerBBucksteinRWellsRARauhMJ

Ligresti, vitamin B12 deficiency is found in populations that consume a largely vegan diet, in older people due to malabsorption, and in people with chronic Helicobacter pylori infection

Before the introduction of chemical fertilisers, the nutrients lost through the harvest were replaced by additional organic matter either from manure, or from humus regeneration during fallow phases