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Acknowledgments We would like to acknowledge the JSS Academy of Higher Education and Research for providing us with all the facilities for research and permitting us to form the Special Interest GroupHuman Genomics and Rare Disorders which has led to the conceptualization of the manuscript

LC-MS/MS Analysis With DDA Samples were injected (30 L) onto an Aeris PEPTIDE XB-C18 100 2.1 mm column, with solid core 1.7 m particles (100 ) fitted with a SecurityGuard ULTRA C18-peptide guard column (Phenomenex, Torrance, CA) using a Nexera UHPLC system (Shimadzu, Columbia, MD) with water (A) and ACN (B), both containing 0.1% formic acid, at a flow rate of 0.3 mL/min (40C)

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