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In this study, PLGA-PEG nanoparticles induced expression of autophagy-associated genes autophagy related 3 ( ATG3 ), DNA damage regulated autophagy modulator 2 ( dram2 ), GABA type A receptor associated protein like 2 ( GABARAPL2 ), and RAB24, member RAS oncogene family (RAB24), (Fig 5A)

Mol Cell Endocrinol 248 , 182191 (2006)

Cancer is a complex, multifactorial disease whose risk of development and progression depends on both intrinsic (oncogenic signaling, epigenetic alterations, genomic instability, and disturbed cell metabolism) and extrinsic (tissue damage, infections, and mutagenic species) factors

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A major limiting factor in the development of new treatments is the lack of predictive pre-clinical models that accurately reflect human disease with regard to liver histology, pathophysiology, and metabolic abnormalities