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This mechanism inhibits the acetylation of FoxO1, reduces the levels of TGF-, connective tissue growth factor (CTGF), and the expression of fibrotic markers collagen I and fibronectin, alleviating the degree of fibrosis

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The altered physicalchemical characteristics significantly impacted the nature of the interaction when these nanosized particles came into contact with biological systems

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To address this issue, X-ray and carbon ion irradiation were performed at a biologically equivalent dose to focus on events leading to an equivalent level of cell death (evaluated with the relative biological effectiveness and clonogenic assays)

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