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Importantly, GMP-compliant experimental studies demonstrate that the transition from research-grade to clinical-grade EVs requires substantial process modifications, including controlled cell sourcing, closed-system manufacturing, scalable purification strategies, and validated quality controls (Humbert et al., 2025)

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Ma Y, Cai F, Li Y, Chen J, Han F, Lin W (2020) A review of the application of nanoparticles in the diagnosis and treatment of chronic kidney disease

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