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The roles of antioxidants in cancer reside on a delicate line of antioxidant or prooxidant mechanisms depending upon the objective of the treatment

Based on previous studies, miRNAs have also been widely proposed as potential targets for treating various cancers

Inhibition of key KRAS upstream and downstream molecules can also effectively inhibit KRAS-mediated signal transduction, such as inhibiting upstream signalling, SHP2, and inhibiting downstream signalling, the RAF-MEK-ERK pathway and the PI3K-AKT-mTOR pathway

To further demonstrate the scalability of CHAMP, we screened a library comprising 1152 azide-bearing compounds that was recently described by the Dong and Sharpless groups in their strategy to install azide tags onto molecules using a diazotizing reagent 32