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Future studies with larger patient cohorts should perform unbiased proteome profiling on blood and CSF samples

TB-500 works specifically through actin regulation and cell migration

In addition, it has been confirmed that the arthritogenicity of RA induced by Syntenin-1 relies on the remodeling of macrophages activated by mTOR and their capacity to cross-regulate Th1 cells through induction of IL-12 and IL-18