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Additionally, it is unexplored whether the intestinal virome modulates autophagy via NOD2

In a model mouse with autism-like behavior induced by prenatal exposure to a cafeteria diet, ADF increased anti-inflammatory CD206 + microglia in the hippocampus, reduced ER stress markers (BiP, ATF6, p-JNK), and improved social interaction

Acta Biochimica Biophysica Sinica 55 (9), 14151424

Evaluation of the efficacy and safety of adjuvant treatment to levodopa therapy in Parkinson s disease patients with motor complications

Although measuring adaptive behavior was not a primary outcome of that trial, the improvements in this assessment gained the FDA's breakthrough therapy label (56)

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