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This enzyme participates in three metabolic pathways: ascorbate and aldarate metabolism, glutamate metabolism, and glutathione metabolism

325,326 In HD, HSP27 exerts neuroprotective effects by suppressing polyglutamine toxicity and lowering ROS levels, thereby slowing neurodegenerative progression

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Furthermore, the integration of NPTAs with focused ultrasound and magnetic targeting is likely to enhance the brain drug delivery efficacy