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Graphical Abstract Access this article Similar content being viewed by others Abbreviations PDC: Polymer drug conjugate EPR: Enhanced permeation effect PEG: Polyethene glycol PHPMA: Poly( N -(2-hydroxypropyl) methacrylamide) PLGA: Polylactic-co-glycolic acid PAA: Poly(acrylic acid) CAP: Cellulose acetate phthalate UPS: Ultra-pH-sensitive PLH: Poly l histidine CS: Chitosan PBAE: Poly(-amino ester)s PDMAEMA: Poly( N,N -dimethylaminoethyl methacrylate pNIPAAm: Poly( N -isopropylacrylamide) GSH: Glutathione PVCL: Poly( N -vinylcaprolactam) PDEAAm: Poly( N,N -diethylacrylamide) ELPs: Elastin-like polypeptides MMPs: Matrix metalloproteinases GPLGIAGQ: Gly-pro-leu-gly-ile-ala-gly-gln GFLG: Gly-phe-leu-gly COPD: Chronic obstructive pulmonary disease IBD: Inflammatory bowel disease ROS: Reactive oxygen species POEGMA: Poly(oligo(ethylene glycol) methacrylate PLC: Phospholipase C PAD: Phosphoramidate dendrimer MPC: 2-Methacryloyloxyethyl phosphorylcholine PDT: Photo-dynamic therapy Vis: Visible NIR: Near-infrared UV radiation: Ultraviolet radiation DNA: Deoxyribonucleic acid UCNPs: Upconversion nanoparticles PCL: Poly caprolactone EDC: 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide NHS: N-Hydroxy succinimide CuAAC: Copper-catalysed azide alkyne cycloaddition PGA: Poly (L-glutamic acid) PEO-PPO-PEO: Poly(ethylene oxide) and poly(propylene oxide) PEG-SS-PTX: Polyethylene Glycol-paclitaxel-disulfide bond PK2: Phosphokinase 2 ADC: Antibody-drug conjugate RGD : Arginine glycine aspartic acid TAT peptides: Trans-activating transcriptor peptide HER 2: Human epidermal growth factor receptor 2 EGFR: Epidermal growth factor receptor PSMA: Prostate-specific membrane antigen TAMs: Tumour-associated macrophages HCC: Hepatocellular carcinoma VEGF: Vascular endothelial growth factor GE11: YHWYGYTPQNVI N-HPMA: N-(2-hydroxypropyl) meth acrylamide DOX: Doxorubicin HPMA: Hydroxypropyl methacrylate CRP: Controlled radical polymerisation RAFT: Reversible Addition-Fragmentation chain Transfer ATRP: Atom transfer radical polymerisation SEC: Size-exclusion chromatography PEI: Polyethyleneimine PAMAM: Poly(amidoamine) FDA: Food and Drug Administration EMA: European medicines agency SCID: Severe combined immunodeficiency AI: Artificial intelligence SAR: Structure activity relationships SPAAC: Strain-promoted azide-alkyne cycloaddition SVM: Support vector machines GNN: Graph neural networks RNN: Recurrent neural networks LSTM: Long short-term memory PINN: Physics-informed neural networks RL: Reinforcement learning CNN: Convolutional neural networks GAN: Generative adversarial networks siRNA: Small interfering RNA GFLG : Gly-phe-leu-gly ScFv: Single-chain fragment variable GalNAc: N-acetylgalactosamine FA: Folic acid RGD : Arginine-glycine-aspartate BBB : BloodBrain barrier CNS : Central nervous system PDX: Patient-derived xenografts EMA : European Medicines Agency ML: Machine learning US FDA: United States Food and Drug Administration References Moeller M, Matyjaszewski K
