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For exogenous antioxidants, the unidirectional two-sample MR analysis exhibited a nominal relationship between the serum retinol level and non-small-cell lung cancer risk (OR = 0.29, 95% CI: 0.110.76, p = 0.011)

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*Correspondence: Mohanned Naif Alhussien, [email protected] These authors share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In fact, the GPx4 protein itself possesses a number of cysteine residues on its protein surface, which have been implicated in its ability to form extensive enzymatically inactive protein polymers (Scheerer et al., 2007)

The challenge now is to integrate this new knowledge and explore how it can be used to categorize patients by molecular phenotype and tailor treatment more effectively