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10.1016/j.neuron.2008.11.024 Neuron 102 HanlonE

The variable domains of naturally occurring heavy and light chains each comprise four FRM regions (FR1 , FR2, FR3, and FR4), largely adopting a -sheet configuration, connected by three hypervariable regions, which form loops connecting, and in some cases forming part of, the -sheet structure

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Perinatal lethality can be caused by a myriad of deficiencies, and determining the precise cause of death in these mice will require many tissue-specific models

In severe cases there may be an involvement of the entire skin surface

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