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Rational design of a polymer with robust efficacy for intracellular protein and peptide delivery

Persistent ferroptosis in alveolar and endothelial cells triggers pro-fibrotic signaling pathways, such as those involving TGF- and connective tissue growth factor (CTGF), which drive ECM deposition and fibroproliferation

Biosens Bioelectron

Aberrant and sustained activation of NF-B is frequently associated with tumour proliferation, resistance to therapy, and poor clinical outcomes

More importantly, there are several aspects of irAEs that we do not understand and which are the source of several controversies in the field

Indeed, recent work has likewise implicated cell cycle arrest, induced either by p53 activation or CDK4/6 inhibition, in sensitizing fibrosarcoma cells to GPX4 inhibition 51