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We identified 46 crosslinks within the DDD-Ube2e2-COP1-c-Jun complex, including 22 intermolecular crosslinks, of which 12 are between COP1 and c-Jun

For example, genes with increased expression following GHK-Cu treatment often exhibit elevated histone H3 lysine 9 acetylation (H3K9ac) marks associated with transcriptionally active chromatin, while genes with reduced expression show decreased H3K9ac and increased H3K9 trimethylation (H3K9me3) repressive marks