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In a series of fluorescence microscopy and biochemical studies, Epitalon was shown to enter the nuclei of human HeLa cells and bind selectively to DNA regions rich in CAG and ATTTC repeats, sequences that are common within promoter regions of the telomerase gene [1,32,33]

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The peptides small size and charge profile allow it to penetrate the stratum corneum, though penetration efficiency depends heavily on the vehicle

and safety concerns around promoting apoptosis given the potential for off-target effects in stem cell populations that share some SASP markers

Low-quality products may contain degraded peptide, incorrect amounts, or contaminants that reduce effectiveness or cause adverse effects

Handbook of molecular-genetic techniques for brain and behavior research (1st ed.)