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Probiotics, SCFA-enhancing diets, and engineered microbial consortia are examples of microbiome-directed therapeutics that can restore metabolic balance, lower luminal endotoxin load, enhance barrier function, and reset peripheral immunological tone [185]

A definitive diagnosis is made by finding increased levels of cystine in polymorphonuclear leucocytes

One major issue is difficulty in attributing mechanisms: It remains unclear whether their neuroprotective effects arise specifically from ferroptosis inhibition or indirectly through anti-inflammatory, anti-aggregation, or mitochondrial protective pathways, and genetic evidence is lacking (e.g., validation in GPX4 conditional knockout models)

Toxicity reduction and efficacy promotion of doxorubicin in the treatment of breast tumors assisted by enhanced oral absorption of curcumin-loaded lipidpolyester mixed nanoparticles