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Although these behaviors might seem beneficial at first glance, they can ultimately lead to malnutrition and social withdrawal

Indika NLR, Vidanapathirana DM, Dilanthi HW et al (2019) Phenotypic spectrum and genetic heterogeneity of cystic fibrosis in Sri Lanka

HIF-1 responds to these changes by specifically decreasing the oxygen (or hypoxia) level, and upregulating several genes to promote survival in low-oxygen conditions and thus promoting angiogenesis