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We replaced the complex equations of enzyme-mediated fluxes of the reduced model (Figure 2A) with simple mass action kinetics in the stylized model (Figure 2B)

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A second cohort of mice including WT, RAMP1 KO, RAMP3 KO, and RAMP1/3 KO genotypes confirmed that both RAMP1 and RAMP3 are individually essential for a full cagrilintide-induced neuronal activation response

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doi: 10.1126/sciadv.abo7639 Summary Keywords ketogenic diet, precision medicine, brain disease, nutrigenomics, neural disease Citation Liu Y, Fan L, Yang H, Wang D, Liu R, Shan T and Xia X (2024) Ketogenic therapy towards precision medicine for brain diseases

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