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10.1210/jc.2015-2913 3 AlviggiC.CariatiF.ConfortiA.De RosaP.ValloneR.StrinaI.et al (2016)

There are seven major causes of a slow metabolism, all of which can be identified and treated

Among patients with 2-year data who underwent early conversion to mTORi (n=93), those who maintained therapy for 1 year experienced improvement in eGFR with a reduction in chronic kidney disease (CKD) stage (29.8% vs 11.1%, p=0.04), particularly among those with 12-week eGFR 65 years old

These differences revealed that independent changes in nutrient acquisition capacity have occurred in the Onygenaceae and Ajellomycetaceae, and underlie how the dimorphic pathogens have adapted to the human host and decreased their capacity for growth in environmental niches

no randomised trial confirmation Long term HD/CKD: 6-mo intravenous improves dialytic symptoms

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