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[DOI] [PubMed] [Google Scholar] 97.Sikiric P., Drmic D., Boban Blagaic A., Tvrdeic A., Krezic I., Gojkovic S., Zizek H., Sikiric S., Strbe S., Smoday I.M., et al

In such scenarios, selenium serves as a countermeasure by forming chelates with these metals, thereby mitigating their harmful impact

doi: 10.1006/exer.1999.0687 50 MaherEF

Common adverse effects observed in clinical trials include nausea, vomiting, injection site reactions, increased heart rate, and hypoglycaemia risk

Research confirmed an estimated half-life of 5.88.1 days in healthy adults

Finally, epigenetic regulatory networks are incompletely characterized: while individual ubiquitinases, miRNAs, or demethylases are implicated, the integrated epigenetic landscape governing ferroptosis in I/R AKI (e.g., crosstalk between ubiquitination and miRNA-mediated silencing, or epigenetic memory of ferroptosis susceptibility) remains unclear