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For example, in a study using hyperspectral imaging, a preparation with 3% kojic acid increased skin brightness in 75% of participants with post-acne discolouration, reduced contrast in 83%, and improved homogeneity in 67%

When DAMPs, such as HMGB1 and ATP, bind to pattern recognition receptors (PRRs) on the surface of DCs (e.g., TLR and NLRP3), they trigger DC maturation, enhance antigen processing and presentation capabilities (86), and promote the secretion of proinflammatory factors such as IL-12 and TNF-, as well as CCR7-mediated lymph node homing

Radiotherapy also increases blood glucose levels and facilitates hybridizations between tumor cells and macrophage/microglia thus producing highly invasive metastatic cells (1, 82, 108, 116118)

Su dficit incrementa la acumulacin de especies reactivas de oxgeno (ROS), que daan las neuronas y desregulan la transmisin nociceptiva

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