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With respect to the use of T1-weighted MRIs to assess gray matter, we note recent commentaries regarding the potential for drug-induced cerebral blood flow alterations to complicate interpretation of structural outcomes [109, 110]

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The data sets and Stata code used for analyses are available from the corresponding author on reasonable request

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The effect of smoking on long-term gray matter atrophy and clinical disability in patients with relapsing-remitting multiple sclerosis