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The pathological effects of oxidative stress on spermatozoa can be grouped into three main categories: lipid peroxidation, DNA fragmentation, and protein oxidation

490 Furthermore, Sir2 , as a mammalian homolog of SIRT1, is the downstream effector of increased Nmnat activity, which can lead to axon protection in Wallerian degeneration slow mice

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The authors concluded that "those with ASDs are affected by an imbalance between their anti-oxidative and oxidative stress systems, a condition which could be treated with glutathione supplementation"

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This interindividual variability has led to the classification of three urolithin metabotypes: the UM-A strain is distinguished by its predominant production of urolithin A, while the UM-B strain produces urolithins A and B, along with their isomers