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238,242 Isocitrate dehydrogenase 3 (IDH3), a pivotal rate-limiting enzyme in the TCA cycle, is downregulated, leading to oxidative phosphorylation uncoupling and lactate accumulation in the brains of AD patients and AD transgenic mice

doi: 10.3389/fonc.2018.00507 52 ZhangR.JiJ.ZhouX.LiR

All these findings suggest the necessity of investigating the mechanisms of the protective effect of MSM, in order to develop strategies capable to increase performance in sport horses