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Briefly, 1 mM stock solution of each compound was prepared in deionized water, diluted to a final concentration of 400 M in PBS (Sigma Aldrich

MetaboAnalyst 6.0 ( was used to process the metabolome data

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doi: 10.3389/fcell.2022.1051311 Received 22 September 2022 Accepted 28 December 2022 Published 23 January 2023 Volume 10 - 2022 Edited by Veerle Janssens, KU Leuven, Belgium Reviewed by Benjamin Neel, New York University, United States Ari Elson, Weizmann Institute of Science, Israel Updates Copyright 2023 Hendriks, van Cruchten and Pulido

During immune responses, microglia release substances such as O 2 and ROS (Block et al., 2007)

In the Structure column, ligand molecules with similar structure to HT, X-ray source and lower value of protein conformation were screened