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Given that HIF-2 is an important transcription factor in cancer progression and leads to poor prognosis 69,70 , these findings suggest that targeting HIF-2 might be an effective therapeutic strategy by inhibiting glutamine metabolism in these notorious cancers

Supplemental short-acting opioids may be used as methadone levels accumulate, especially for patients previously utilizing fentanyl (e.g., oxycodone 10-20 mg titrated to effect)

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Lastly, the heightened activity of the glucose monophosphate shunt results in excessive NADPH consumption, thereby depleting the cofactor necessary for the synthesis of glutathione (GSH)

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

Les enfants ont des besoins diffrents et une dose infrieure serait ncessaire