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Several factors contribute to the acquisition by retinal microglia of a pro-inflammatory phenotype during ageing, including altered metabolism and reduced immunomodulatory signals from retinal neurons, such as the CX3CL1-CX3CR1 and CD200-CD200R signaling pathways, resulting in increased microglial activation ( As with microglial cells, astrocyte activation is also one of the hallmarks of physiological ageing (Nichols et al., 1993

Cell 75 , 487493 (1993)

It should be noted, however, that only the short/medium-term effects of GSH supplementation were evaluated during this trial

Gutman has transitioned from a top-level emergency physician to a global advocate for health optimization through natural, evidence-based solutions

Wilson JC, Furlano RI, Jick SS, Meier CR

But before you dive into the world of milk thistle (or any new supplement, for that matter), we always recommend checking in with your healthcare provider first