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I remember talking to a practice manager in a busy clinic last month

In a 2-year trial, acute pancreatitis was reported in 8 semaglutide-treated patients (0.27 cases per 100 patient-years) and 10 placebo-treated patients (0.33 cases per 100 patient-years), both on a background of standard of care.1 In trials of patients receiving oral semaglutide, pancreatitis was reported as a serious adverse event in 6 patients (0.1 events per 100 patient-years) receiving semaglutide versus 1 in comparator-treated patients (less than 0.1 events per 100 patient-years)

The thigh has slightly denser nerve distribution in some areas compared to the abdomen

National Research Council (US) Subcommittee on Laboratory Animal Nutrition

The most common adverse events were mild-to-moderate headaches, similar in frequency to placebo groups

Although this area of study is still emerging, it highlights potential new directions for understanding NNMTs role in adipose biology