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There are a number of ways that someone may develop a vitamin B12 deficiency

One study reported that flu shots were the most commonly reported cause

In diet-induced obesity animal models, NNMT inhibition demonstrated metabolic changes including alterations in adipocyte lipid content without affecting food intake patterns, coupled with significant reductions in white adipose tissue mass in treated mice

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Research shows that blocking NNMT in fat tissue leads to higher energy expenditure 1