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At first glance, this may seem an appropriate and straightforward way to quantify the treatment effect, but there are several reasons why the placebo-adjusted effect sizes of a drug in RCTs do not necessarily indicate the effect sizes that are achieved in real-life patient management

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Kelz MB, Chen J, Carlezon Jr WA, Whisler K, Gilden L, Beckmann AM et al (1999)

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Transplantation of gut microbiota derived from Alzheimer's disease mouse model impairs memory function and neurogenesis in C57BL/6 mice

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